Krebsforum Lazarus

Zur Zeit gibt es in mehreren Ländern gibt es Keuchhustenausbrüche, teilweise mit mehr als 20.000 Erkrankten. Das ist mehr als 10x soviel wie in den Jahren vorher.

Betroffen sind außer USA und Australien auch Großbritannien und andere europäische Länder.

Keuchhusten betrifft Menschen jeden Alters. Erwachsene können lange Zeit Keuchhusten haben, den sie aber gar nicht bemerken. Sie können unterdessen Andere infizieren, vor allem Kinder - gerade Säuglinge sind besonders gefährtdet.

Die Impfung ist kein lebenslanger Schutz. Deswegen sollten auch Erwachsene ihren Impfschutz unbedingt auffrischen!

Keuchhusten ist sehr gefährlich und kann außer zu bleibenden Schäden auch zum Tod führen. Und es gibt bereits mehrere Tote!


Dana wurde nur vier Wochen alt:



http://littlelioness.net/2012/05/05/vacc…r-kids-stopavn/

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Curry compound could fight cancer; Curcumin may kill bowel cancer cells
Curcumin -- found in turmeric -- mayn enhance the effectiveness of chemotherapy

AFP RELAXNEWS
Published: Tuesday, May 8, 2012, 2:03 PM

Scientists hypotheize that curcumin, found in the Indian spice turmeric, can help improve the drug response in patients with advanced bowel cancer.

A team of British researchers has launched a clinical trial that will look at whether a compound found in curry can improve the drug response in patients with advanced bowel cancer -- the third most common cancer worldwide after lung and breast.

It's a study that will try to improve current bowel cancer treatments which either have a lackluster effectiveness -- only about 40 to 60 percent patients respond -- or cause severe side effects like tingling and nerve pains, researchers explained in a release.

The aim of their research will try to confirm previous studies which likewise found that curcumin -- found in turmeric -- can enhance the ability of chemotherapy to kill bowel cancer cells in the lab.

"Once bowel cancer has spread it is very difficult to treat, partly because the side effects of chemotherapy can limit how long patients can have treatment," explained lead investigator William Steward in a statement. "The prospect that curcumin might increase the sensitivity of cancer cells to chemotherapy is exciting because it could mean giving lower doses, so patients have fewer side effects and can keep having treatment for longer."
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more:
http://www.nydailynews.com/life-style/he…ticle-1.1074477

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30 April 2012 Last updated at 06:45 GMT

'Brake gene' turned off in pancreatic cancer
Pancreatic tumour The gene was turned off in 15% of pancreatic cancers

Aggressive pancreatic tumours may be treatable with a new class of drugs, according to Cancer Research UK
[...]
A study, published in the journal Nature,
http://www.nature.com/nature/journal/vao…ature11114.html
showed that a gene was being switched off in the cancerous cells.

The reseachers said drugs were already being tested which had the potential to turn the gene back on, to stop the spread of the cancer.

Around 7,800 people in the UK are diagnosed with pancreatic cancer every year and it is the fifth most deadly cancer.

"“Start Quote
These results raise the possibility that a class of promising new cancer drugs may be effective at treating some pancreatic cancers”

(Dr Julie Sharp Cancer Research UK)


On/off

Studies in mice showed that a gene called USP9x, which normally stops a cell from dividing uncontrollably, is switched off in some pancreatic cancer cells.

The gene is not mutated, but other proteins and chemicals become stuck to it and turn the gene off.

Studies then showed that UPS9x was being turned off in human pancreatic cancer.
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more:
http://www.bbc.co.uk/news/health-17870315
http://www.nature.com/nature/journal/vao…ature11114.html

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The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

Journal name: Nature
Year published: (2012)
DOI: doi:10.1038/nature10983

Received 24 April 2011
Accepted 22 February 2012
Published online 18 April 2012

Abstract

The elucidation of breast cancer subgroups and their molecular drivers requires integrated views of the genome and transcriptome from representative numbers of patients. We present an integrated analysis of copy number and gene expression in a discovery and validation set of 997 and 995 primary breast tumours, respectively, with long-term clinical follow-up. Inherited variants (copy number variants and single nucleotide polymorphisms) and acquired somatic copy number aberrations (CNAs) were associated with expression in ~40% of genes, with the landscape dominated by cis- and trans-acting CNAs. By delineating expression outlier genes driven in cis by CNAs, we identified putative cancer genes, including deletions in PPP2R2A, MTAP and MAP2K4. Unsupervised analysis of paired DNA–RNA profiles revealed novel subgroups with distinct clinical outcomes, which reproduced in the validation cohort. These include a high-risk, oestrogen-receptor-positive 11q13/14 cis-acting subgroup and a favourable prognosis subgroup devoid of CNAs. Trans-acting aberration hotspots were found to modulate subgroup-specific gene networks, including a TCR deletion-mediated adaptive immune response in the ‘CNA-devoid’ subgroup and a basal-specific chromosome 5 deletion-associated mitotic network. Our results provide a novel molecular stratification of the breast cancer population, derived from the impact of somatic CNAs on the transcriptome.

Figures at a glance
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more:
http://www.nature.com/nature/journal/vao…ature10983.html

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http://www.sciencebasedmedicine.org/inde…-versus-europe/

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